How have we met the challenge?

Asymmetric Suzuki Reactions Limited has developed several efficient methodologies to access the most promising drug candidates. We have made a ‘bank’ of diverse 3D molecules containing polar functional groups and heterocycles.

This bank has been efficiently constructed using highly enantioselective, asymmetric variants of metal-catalysed coupling reactions. The powerful carbon-carbon bond disconnection accesses the unique and diverse 3D scaffolds from simple precursors, and tolerates the polar functional groups and heterocycles that often lead to synthetic failure using other methodologies but which are vital to success in drug development.

Each reaction is carefully optimised: computational and mechanistic study allows us to design custom ligands which deliver the best results.

Asymmetric Suzuki Reactions Limited can now deliver these outputs to industry, so expanding the efficient search of chemical and structural space for drug discovery.